![]() ![]() Shaw and his team hope to launch clinical studies in humans in the next three to five years. Results show that upon directly injecting the protein into the hearts of mice, heart failure can be reversed, and mortality reduced. In preclinical studies, Shaw and his colleagues have been attempting to restore levels of cBIN1 via gene therapy. The protein forms little baskets, or “microdomains,” that collect and organize the important proteins that make a heart contract and relax. Shaw’s studies have also revealed the role that cBIN1 plays in individual heart cells. With a staff of nearly 100 researchers spread among 14 laboratories, the CVRTI is the largest free-standing collection of cardiac muscle biology, metabolism, and electrophysiology researchers in the country.Īmong the institute’s recent discoveries spearheaded by Shaw is that heart failure progression is associated with decreased levels of a protein called cardiac BIN1, or cBIN1. He is one of the many scientists at U of U Health’s CVRTI dedicated to answering vital questions about how to heal a failing heart. Nora Eccles Harrison Cardiovascular Research and Training Institute This “cell to bedside” approach is designed to develop novel diagnostics and therapeutics for failing hearts. Shaw’s lab studies how cardiac ion channels are formed and how they are targeted to specific subdomains of cardiac cell membrane in both healthy and failing heart muscle. These proteins are responsible for propagating the electrical signals that make the heart contract, and changes to their function or distribution across the heart’s surface can contribute to heart failure. His research focuses primarily on complex proteins called cardiac ion channels. Shaw has spent his career finding ways to reverse these troubling trends. "Current therapy is in the stone ages relative to medical therapy for many other diseases." “How can we make this heart muscle better?” “What we don’t do a good job of is addressing the heart itself,” said Shaw. But these medicines were developed for other conditions, such as high blood pressure, and not specifically for heart failure. She's an international life coach and author mentor, and a full time world traveler with a home base in Portland, Oregon with her best friend, her Golden Retriever Chance, who she flew to China to Rescue.Doctors often prescribe heart failure patients drugs such as beta-blockers, angiotensin converting enzyme inhibitors, and aldosterone inhibitors. ![]() Her website has been names top 75 Personal development websites and top 100 self-help websites by the institute for the Psychology of Eating. She's been named one of Entrepreneurs Must-Follow Instagram Accounts for Inspiration and Top Facebook Accounts for Daily Motivation by Mind Body Green. She's been named top 100 Women to Watch in wellness by mindbodygreen, alongside Cameron Diaz, Gwyneth Paltrow, Kris Carr and Gabriel Bernstein, and was listed as of the freshest voices in mental health and wellness by Chicken Soup for The Women's Soul. As an international life coach, speaker, and retreat leader, she helps people awaken and align with their true selves so they can live their highest potential. in journalism and communications from the University of Oregon. Shannon Kaiser is the best-selling author of 5 books on the psychology of happiness and fulfillment including The Self-Love Experimentand Adventures for Your Soul, Joy Seeker, and Unshakable Inner Peace Oraclecard deck, and the forthcoming book Return to You.
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